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According to the literature, these two medications are safe together, and with someone taking Wellbutrin for depressive symptoms that has hypomanic / manic periods (common with bipolar disorder), Lamictal help stabilize the mood in order to decrease the risk of a manic episode. In my own experience, this combination caused severe neck and Back pain to the point where I could not move my neck for a day (this was after taking the combination for 2-3 days, after I discontinued the Lamictal, the pain went away). I have read reports of a similar reaction in others. Also, it seemed to make my concentration worse (I was diagnosed as bipolar d/o, yet I don't have the manic phases.. I'm almost certain it's actually ADHD).

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Q: Are there risks to taking Wellbutrin XL and Lamictal together?
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Can Wellbutrin be taken with lacmictal?

Both wellbutrin and lamictal are central nervous system depressants and the use of these two drugs should be monitored when taken together. It is also important to recognize that the risk of unwanted effects may increase with use. Some possible side effects may include, ataxia, confusion, drowsiness, respiratory depression, and weakness. The benefits of the combined use of these two medications usually outweigh the risks. Timing and dosage play a factor in the interaction of the two. You should talk to your doctor if you have any concerns.


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