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No, this would exceed the recommended dose of acetaminophen. However, you could take just a Benadryl (diphenhydramine) with the Tylenol 3. It is the ingredient in Tylenol PM that makes you sleepy, without the extra acetaminophen.

Tylenol PM contains 500 mg of acetaminophen and 25 mg of diphenhydramine.

Tylenol 3 contains 300mg of acetaminophen and 30mg of codeine.

Recommended doses for adults are:

  • 300-500 mg of acetaminophen every 4-6 hours, or up to 1000 mg every 6 hours; not to exceed 4000 mg of acetaminophen during a day
  • 25-50 mg diphenhydramine every 4-6 hours, not to exceed 50-100 mg every 4-6 hours
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10y ago
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14y ago

Tylenol Extra Strength contains just acetaminophen, an analgesic for pain and fever relief. Tylenol PM contains both the acetaminophen and diphenhydramine. Diphenhydramine is an antihistamine that is used as a sleep aid to help you get to sleep.

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11y ago

No u can not this will cause the nervous system to shut down !

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8y ago

No. Too much Tylenol can cause liver damage.

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Q: Can you take Tylenol PM with Tylenol 3?
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