I'm not a doctor, but if you're considering doing what I think you want to do--substituting your own urine for someone Else's to pass a drug test, or vice versa Don't do it. To answer your question--if there is any significant difference between the urine of a man or a woman...I'm not sure, but I would guess there is no significant difference between the urine of a man or a woman, save for if the woman is pregnant. As you may have considered--pregnancy tests can be conducted using urine. So if the woman is pregnant...you'll have issues. It'd be best to use the urine of a guy, just to be safe.