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I can speak only on the latter part of your question, the Vicodin. Vicodin is an opiate, and any opiate, even in smaller doses, can affect your histamine receptors and cause hives or itching, little red bumps all over your body that itch something awful.

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Q: Can novacaine or vicodin cause you to break out in an itchy red somewhat swollen rash on your limbs?
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