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No, it is not safe to mix any of these medications at anytime. Here is a full list of the drug interact effects. If you have any concerns or questions please contact your Doctor or Pharmacist. Ativan (Lorazepam) and Hydrocodone (Ingredient of Vicodin) (Moderate Drug-Drug) MONITOR: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients. MANAGEMENT: During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

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15y ago
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Andrew Landgren

Lvl 3
4y ago

You can mix them, you can mix most drugs. Can you mix them safely? No

Methadone, although less appealing, has a more dominant bond to your opioid receptors than Vicodin. Therefor, you usually won't feel the effects of the Vicodin.

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10y ago

Yes, The Methadone will usually overpower the Vicodin

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Wiki User

12y ago

i wouldn't but it would be safer than taking a downer that's not opium based with it

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Q: Can you mix adavan with Vicodin?
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