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You can, but they are typically not prescribed together since they perform the same function - long term dosage delivery of opiate for chronic pain. They can be prescribed together when the patient is making the transition from OxyContin to Duragesic or vice-versa, but there's really no reason for it. All Duragesic patches come with information instructing the patient and doctor on the minimum starting dosage with a morphine equivalence chart that allows them to estimate your current equivalence with the drug you're using to the equivalent Duragesic dosage. Janssen Pharmaceuticals does skew the dosage estimates lower than they normally should be though for safety reasons, since all patients should start at the lowest dose and then work up to maintenance levels.

The difference is in the time factor - OxyContin has an advertised dosage time of 12 hours effective dosage, while Fentanyl patches are good for either 48 to 72 hours depending on the individual. For most people it's 72 hours, but a small percentage of the population (myself included) only gets 48 hours.

Since they're both controlled delivery drugs, Fentanyl patches are often prescribed when OxyContin tolerance has lowered to the point where the patient is only getting relief for about the same time that an acute pain medication does - just over 6 hours. Before I started using Duragesic, I was barely getting 7 hours out of OxyContin. The idea in pain management is to maintain a controlled dosage with less medication at a steady rate over long periods so that the patient doesn't have to rely on more medication to achieve the same results. Of course as tolerance increases, dosages may have to be adjusted, or increased if the pain increases. I've had to do this several times over the many years I've used Duragesic, but ultimately was able to return to my normal dosage levels after the reason for increased need was dealt with.

the fentanyl patch is a long timed system patch in which it lasts up to 72 hours per patch and dosage in your system compared to the tablet of Oxycontin in which it only lasts about 6-8 hours per pill depending on dose and your tolerance of pain medications

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13y ago
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14y ago

Yes - Norco is a combination of Hydrocodone and Tylenol. Though most Duragesic patients use stronger breakthrough meds (I use Percocet 10/325's, which is Oxycodone/Tylenol) it of course depends on your patch dose and overall requirements. The patch is your primary pain control, delivering a constant maintenance dose over 2-3 days. Your acute med is for breakthrough pain, caused by increased activity or life just happening to suck that particular day. Either way, it's very common for patches to be prescribed with an acute medication.

It can take some time for new patients to adjust, but it doesn't take long to learn the drill.

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12y ago

Yes, you can, as long as the doctor or pharmacist which prescribed you the oxycodone and fentanyl told you that you can take oxycodone and fentanyl together. Remember that taking them in combination can cause respiratory arrest (inability to breathe) thus resulting in death.

A warning to this though: All three drugs depress the central nervous system, which results in drowsiness. Taking them all together can result in a loss of motor function and sleepiness, so be careful with that.

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15y ago

If you have a tolerance to fentanyl and xanax then yes. Otherwise it's a common way to overdose on drugs due to users basically "suffocating" due to severely depressed breathing.

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11y ago

Yes - it's not uncommon for chronic pain patients who use Fentanyl patches to take Xanax or other similar anti-depressants, as depression very common with anyone who has serious pain issues.

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12y ago

you sure can

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Q: Is it safe to take trazodone and Fentanyl patch together?
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