Can I take methotrexate and clindamycin together?

Answer 1

It has in fact been noted in a large number of cases that clindamycin appears to reduce the blood level of methadone in methadone maintenance patients, hence causeing acute methadone withdrawl. This has not been proven, but a correlation has been shown in numerous cases in which methadone maintenance patients have been prescribed a cycle of clindamycin, only to return to the doctor with reports that the clindamycin made them feel even sicker than they had been in the first place. I am not a doctor, I am the boyfriend of a 22 year old woman who has been on methadone maintenance for 3 years. Recently, she had a dental infection for which the physician at the walk-in clinic prescribed clindamycin. She took it for a few days, and with each passing day she felt sicker and sicker, in a way that she could only associate with acute opioid withdrawl. Finally, she came to the theory that there may be some kind of negative reaction between the two medications, and looked it up on the internet. Upon reading various articles and reports, she found that she was not alone, and that there was scientific evidence that implied an adverse reaction between these two drugs, and that the result could be withdrawl. There are lots of antibiotics available now, and if you are alergic to one or more, you still have a palette of options. Consider it an allergy, if you are on methadone, then you can just tell your doctor that you are allergic to clindamycin, or that you are on methadone and have read on wiki answers that clindamycin is known to have a negative effect on methadone treatment.

Answer 2

Firstly I AM NOT A DOCTOR, however I have been taking Methadone for 5 years now, as I under stand it Clarithromycin greatly reduces your body's ability to "Break down" Methadone (It affects the enzyme) so that there is a danger of overdosing on Methadone.

If you are a patient at a Methadone clinic as I am then talk to your doctor there as I am not sure if there is a "safe dose" level.

Answer 3

These two medications should be safe to take together. Check with your doctor or pharmacist to be sure that this is a good combination for you.

Answer 4

Not all antibiotics! Some antibiotics taken with methadone will make you have symptoms of withdrawal.

Answer 5

Yes. There is no interaction between the two.