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I can only answer anecdotally. It appears that Wellbutrin & Zyrtec do react when used together. When my Wellbutrin got up'd to 300mg (I also take 100mg of Zoloft), the Zyrtec made me incredibly sleepy to the point where I felt drugged & would not have felt comfortable driving a car. Normally Zyrtec does not make me sleepy even when I was on 150mg of Wellbutrin with 100mg of Zoloft or on 200mg of Zoloft alone. I will keep taking the Zyrtec but will take it before bed now. If you need to take both, I strongly suggest trying when you have nothing to do & nowhere to go.

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Wiki User

13y ago
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Wiki User

11y ago

Yes, you can, and I have been prescribed 50 mg of Pristiq with 300mg of Wellburtin xl-taking the wellbutrin in the am, and Pristiq at any time of the day, but try to keep it the same time-it has a short half=life. Good Luck to you if you try this combination!

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keclay

Lvl 2
3y ago

No, these drugs can cause interactions. I almost died from taking both because it made my Allergies infinitely worse. I was reacting to the inactive ingredients in all of my meds and had to go to the emergency room.

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keclay

Lvl 2
3y ago

I wouldn't risk it. There can be interactions. I almost died. Since there are so many antihistamines and also so many antidepressants, it shouldn't be hard to find two drugs that will be less likely to cause problems.

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Wiki User

14y ago

* •CNS depressants may increase depressant effects. * •MAOI may prolong and intensify anticholinergic effects of antihistamines: •Increased dry mouth, drowsiness, etc.

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Wiki User

12y ago

Yes, Zyrtec is a antihistamine and wellbutrin is an antidepressant. There shouldn't be any interaction with the two, but its always helpful to ask a pharmacist.

-Pharmacy tech

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Q: Can you take pristiq and Wellbutrin XL?
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