Did Frances Perkins have any children?
Frances Perkins had one daughter. Susannah Coggeshall.
Frances Perkins was married to Paul Wilson, an economist. Several years after the marriage, Wilson became ill; as a consequence, he wasn't able to work for much of his adult life, which meant that Frances Perkins had to support herself, her husband, and their daughter on her salary alone. His medical bills were also very large.
You are asking about Frances Perkins, who served as US Secretary of Labor from 1933 to 1945; she was appointed to that post by President Franklin Roosevelt. (An interesting fact about her was that she was one of the few women back then to keep her name; she was married, but always used "Frances Perkins" rather than Mrs. Paul Wilson.)