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Basically, no. Assuming a standard H&E stain, Serous cells will stain darker, and appear much more granular as their secretions contain large quantities of enzymes (namely Lysozome), hence you will also find the serous cells also contain large quantities or Rough ER, required for protein (enzyme) manufacture. Mucous cells secrete mucin, which has a large water carrying ability, and so you will find mucous cells (such as goblet cells, or mucous cells of the sublingual gland) stain much clearer in comparison to serous cells. A good histological comparison of these different cell types can be made by looking up a couple of the salivary glands. A parotid gland, which will have large numbers of serous cells (heavily stained), and also a few adipocytes dotted about the place (these will be stained VERY clear). A sublingual gland will have large numbers of mucous cells, and just a few serous cells dotted about the place. If you then look at a submandubular gland, this would be good for comparison, once you've got the hang of what the different cells types look like, as this gland has a fairly even mix of serous and mucous cells. If you don't have access to a microscope and prepared stained sections, then there's plenty of images on the web, or in Histology text books. Hope this helps. Will UK Medical Student

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Q: Do mucous cells and serous cells stain the same?
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