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I have taken Seroquel with Ambien many times. They work well together for those nights I just can't get to sleep.

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Q: Does seroquel and Ambien cancel each other out?
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I would not take two drugs which both make you sleepy right on top of each other. You should always try to get to sleep without getting dependent on the Ambien, and only take it if you cannot fall asleep. Take the Seroquel first, before bedtime. If you are not sleepy enough to fall asleep after 30-60 minutes, then you can take an Ambien if you want. Just popping an Ambien every night because it's bedtime only makes you dependent on the drug and makes it impossible for you to get a normal night's sleep.


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