E85 fuel in a nonE85 vehicle is it safe to operate?

Short answer is no. The use of pure E85 in standard gasoline car engines will void the manufacturer's warranty, may disrupt oxygenation control in fuel-injected cars, and may result in power loss. It may also interfere with proper operation of the catalytic converter. E85 can also cause engine damage, since prolonged exposure to high concentrations of ethanol may corrode metal and rubber parts in older engines (pre-1988) designed primarily for gasoline. Post-1988 fuel-injected cars are designed to accept E10 fuel, and may be tolerant of higher concentrations of ethanol to varying degrees, usually up to at least 20%. Check your owner's manual to see exactly what the fuel requirments are for your vehicle.