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HIV is a very complex, highly changeable virus. Even if it gets killed by the medicines or vaccines, it gets reactivated. Scientists are continuing to make and test HIV vaccines in animals, and even in human subjects.

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9y ago
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14y ago

HIV has a very high mutation rate, a rapid reproductive rate, and an enormous population size. This means that at any given time, a human infected with HIV is carrying tens of millions of HIV virions with millions of different random mutations. Inevitably, sooner or later, a mutation will occur that confers resistance to AZT. (This will typically be a mutation that causes greater selectivity in the active site of the reverse transcriptase enzyme.) Notice that the HIV population has heritable variation for resistance to AZT before exposure to AZT. However, at this stage the resistance to AZT occurs only in one or a few virions, out of the billions.

Step two is for the patient to begin taking AZT. This prevents or slows replication of most HIV virions, and those strains die out. But the lucky virion with the right mutation will survive and will be able to replicate.

The surviving HIV virions then repopulate the host. Soon the entire HIV population is composed of resistant virions.

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14y ago

It is hard because HIV Is Humane Immunodeficiency Virus, Which effects your Immune system. Destryong it's capability to fight off other diseases, making it almost impossible to create an Vaccine because vaccinations are dead virus's that warn your immune system to begin with.

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11y ago

hiv is a retrovirus...it enters the cells damaging our dna and making its own dna with reverse transcriptase and thus executes command suprressing our immune system and lead us to opportunistic infections... it is not posible to regenerate our own body dna and boost up the immune system and plus this virus mutates in our body quickly

.. so it is not possible..

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14y ago

Part of the problem in developing an effective vaccine so far has been the issue of mutation. The HIV virus mutates, or changes, rapidly.

What this means for vaccine research and development is that as we are studying the virus and figuring out what will be effective against it, it changes, making whatever we have so far come up with ineffective.

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7y ago

It has a high mutation rate causing different strains.

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11y ago

It is difficult to develop a vaccine because the virus changes (mutates) very quickly. Thus scientists do not have a stable target to make the vaccine against.

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Q: Why is it difficult to vaccine against HIV?
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Related questions

Can hepatitis B cause HIV or AIDS?

No. Hepatitis B and HIV are two different viruses. One does not cause the other.


Why is it difficult to develop HIV vaccine?

Part of the problem in developing an effective vaccine so far has been the issue of mutation. The HIV virus mutates, or changes, rapidly. What this means for vaccine research and development is that as we are studying the virus and figuring out what will be effective against it, it changes, making whatever we have so far come up with ineffective.


What antiviral vaccine is able to fight HIV?

There is no vaccine for HIV at this time.


Is there a vacciane for HIV?

No; there is no vaccine for HIV.


Why there is no vaccine HIV virus?

The HIV virus has proven difficult to fight for a number of reasons. One of them is the fact that the virus mutates quickly. That means that the virus changes at the genetic level, making finding a vaccine that works for all variants of the virus difficult if not impossible, thus far.


How does the HIV vaccine help to prevent chickenpox?

There is no commercially available HIV vaccine as of 2014.


Is HIV a stable virus can it mutate?

The HIV virus is highly unstable, meaning that it does mutate quickly. That has been part of the dilemma in finding a cure, or even a vaccine against the virus.


It is difficult to develop vaccine for aids why?

HIV is a RNA virus, which means it goes through lots of mutations. A vaccine depends on some of the same immune responses produced by natural infection to create a "memory" of the virus. For HIV, this is particularly hard because the immune system cannot create broad enough antibodies; an antibody created for one HIV virus might not work for another HIV virus, which most likely would have evolved. Thus, our killer T cells cannot recognize the HIV virus many times, failing to defend our bodies against HIV.


AIDS can be prevented with a new vaccine called AZT?

Scientists and researchers have been searching for an effective HIV vaccine for many years. Because of HIV's ability to mutate so rapidly however, it has been difficult to develop an effective vaccine. Studies continue, but increasingly the opinion is that an effective vaccine is still many years away. But even when there is an effective HIV vaccine, it will not mean that there is a cure for HIV. A vaccine will help to keep uninfected people uninfected but will not directly benefit people who are already living with HIV/AIDS. The ongoing advances in HIV treatment are increasingly becoming what could be considered to be a "cure" for people living with HIV/AIDS. These medications, when taken as directed, can help diminish the impact that HIV has on the body and allow people living with HIV to live long and productive lives.


Is it true that a vaccine for HIV and AIDS was found but some people are hiding it from people?

There is active research into making a vaccine against HIV. Claims that one has been found may be based on preliminary research findings. None have yet proved to be effective and safe enough to warrant mass immunization.


Virus without a vaccine?

HIV would be one.


Should all hospital personnel should be vaccinated for HIV.?

There is no available vaccine for the HIV virus.