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i have and dr. said it was a sign of bipolar. wellbutrin is, indeed, sometimes used to treat bipolar...but the immediate release and the SR version are not used as often, now that the XL (once a day) version is out. He switched me to the XL version and the problem went away. P.S. wellbutrin works on dopamine and norepinephrine. dopamine, he thought, was the problem. another answer: It seems to be a major problem in a small percentage of people who are taking Wellbutrin. Researching on the web, I have come across quite a few comments on this subject and most of the people experiencing this seem to experience actual rage as opposed to minor irritability. I had problems with this myself a couple of years ago. I have been told on many occasions that I am an extremely laid-back individual, but after I started taking wellbutrin I noticed that even small things started to cause me to experience almost uncontrollable anger. I lost a great deal of tact in dealing with other people and I had this constant nagging feeling that I had to leap into a conversation whether or not I had anything useful to add or was even welcome. It caused me a huge amount of stress knowing that I was acting extremely out of character and seemed unable to do anything about it. I was almost hospitalized as it continued to worsen, had to leave work, and spent a great deal of time afterwords fearing that I had forgotten how to be myself around others. I was fine after I stopped taking it, but recently my doctor had me start a low dosage to see if it would help my energy level which was lagging thanks to cymbalta. I have noticed in just a week, on the lowest dosage he could get me, that I have already started bulling my way into conversations (I am a very soft-spoken, polite person), speaking up and feeling very surprised about it as I had not intended to, experienced an increase in tics and intrusive thoughts (from my OCD), and have started to have a scarily familiar feeling in my general manner that basically is like a dangerous bully living in my head and just waiting to surface. This proves to me that the past episode was not in fact due to health problems I was exeriencing at the time, but was, in fact, the wellbutrin.

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โˆ™ 2007-10-24 14:10:19
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Q: Has anyone experienced unusual anger or rage shortly after starting Wellbutrin?
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AnswerFrom a medical standpoint it is not uncommon for a combination of medications to use used to treat ADHD. A combination of Concerta (methylphenidate), Strattera (atomoxetine), and Wellbutrin (bupropion) is somewhat odd but not extreme. Both Concerta and Strattera are approved to treat ADHD, Wellbutrin is not although there is some evidence it can be helpful in people with ADHD, particularly those who fail to adequately respond to stimulants.It is perfectly appropriate and fairly common for two medications to be used at one time, typically a stimulant like Concerta and either Strattera or Wellbutrin. It is not unheard of for two stimulants like Concerta and Adderall to be used together or for Strattera and Wellbutrin to be used together. Often adding either Strattera or Wellbutrin in a conventional stimulant like Concerta can provide better symptom control.Concerta and Strattera have no significant drug interactions however both have some interaction with Wellbutrin, which may increase plasma concentrations of Strattera and there is a slight increase is seizure risk when combining Concerta with Wellbutrin. However the risk is very minor and people with no history of epilepsy are unlikely to have a problem. Risk of seizure when taking Wellbutrin is typically about 0.4%.Simply put there is no medical reason all three medications can't be used at the same time although it is, as it always is, important to monitor for side effects. But using three medications is uncommon however doctors are able to prescribe unusual combinations of medication because some people require a more novel treatment.As always if you have any concerns or side effects please tell your doctor. Do not increase, decrease, or stop medication without talking with your doctor.Anecdotal answerNo. But if you really have a concern you should consult with the prescribing doctor. You could be on one of the medications until the others kick in. Or you could simply be taking a low dose of all 3. From the Wellbutrin (and not being a prescribing doctor) it's hard to tell what the direction is here... you could have been given the Wellbutrin to offset side effects, or to work with one or both of the other medications. Wellbutrin does have stimulant properties, more so than Strattera, however neither drug has stimulant effects like Concerta. If you are not feeling comfortable with these medications be sure to talk with your doctor. Only he can explain his reasoning or he may change the prescription altogether. As far as being a weird combination... no it's not.

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