However improbable it can be done through a combination of rain delays, traded players, batting out of order, bases loaded HR in which appeal for batter not having touched first base would negate all other runners etc...
Unless you're pinch hitting for people in the middle of their at-bats (which to me is cheating for the purposes of this question), it's impossible. The maximum number of batters you can send to the plate in an inning without scoring is six.
There have been three pitchers to strikeout 20 batters in one game and one pitcher to strikeout 21 batters in a game. The three to strikeout 20 were Kerry Wood, Roger Clemens, and Randy Johnson. All three struckout all those batters in a nine inning game. The pitcher to strikeout 21 batters, Tom Cheney, needed 16 innings. Cheney's 21 strikeouts is the MLB record for strikeouts by a pitcher in a single game.
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