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A combination of old age, Porphyria (the cause of his 'madness') and arsenical poisoning. Arsenic was a common ingredient in all sorts of preparations, including hair powder, wallpaper and mixtures used to whiten milk; it was not uncommon for people to build up considerable quantities in their tissues over time.
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∙ 11y ago
Wiki User
∙ 13y agoWiki User
∙ 12y agoThe rule of King George III of Britain ended when he was seen to be insane and a Regent was appointed. However, the reign of King George ended when he died.
Wiki User
∙ 12y agoHe suffered mental breakdowns
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George III
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