How does a person inherit cystic fibrosis?

Answer 1

For a baby to be born with Cystic Fibrosis, both parents must be carriers of the faulty CF gene. Where both parents carry the faulty gene, each child has a one in four chance of having CF, a two in four chance of being a carrier and a one in four chance of not having any CF genes.

Answer 2

The severity of symptoms in cystic fibrosis varies from person to person, but over 90% of people with cystic fibrosis have measurably saltier sweat than other people without cystic fibrosis. Doctors use the sweat test – which measures the amount of the salt in the sweat – to diagnose most cases. Instead of making the subject run around the clinic to work up a sweat, sweat is collected from the forearm with the help of a weak electric current and a sweat-inducing chemical called pilocarpine. An electrode filled with pilocarpine is placed on the inner forearm, while the other electrode is placed on the outer forearm. Current runs for five minutes – making the arm feel tingly or warm – to deliver the pilocarpine under the skin. Once the electrodes are removed and the arm rests for four minutes, a piece of filter paper soaks up the sweat where the pilocarpine-filled electrode was attached. The filter paper is placed into a flask after 30 minutes of sweat collection, and the sweat is rinsed from the filter. A machine called a digital chloridometre measures the concentration of chloride ions in the sample. A reading above 60 mmol/litre indicates the person has cystic fibrosis. In cases where the sweat test is inconclusive or impossible to administer, genetic testing can diagnose the disorder. Because there are over 900 mutations that can cause Cystic Fibrosis, geneticists begin testing by searching for the most common mutation – Delta F508. Delta F508 is named for the missing phenylalanine at position 508 in the CFTR protein. The corresponding mutation is a deletion of three bases – CTT – near the beginning of the gene. A DNA test detects this mutation through the use of small molecules called primers. GO TO THIS WEBSITE. IT IS VERY GOOD http://www.ygyh.org/cf/inherited.htm

Answer 3

All through the genes and alleles.

Cystic fibrosis is a genetic disease and can only be inherited through genes.

It all depends on your parents alleles. Let's say that the allele for cystic fibrosis is c. If your Mum has the allele Cc it means she is hetrozygous. If you Dad has the same allele he is also hetrozygous. When they had children, the two small c's could come together to make a child with the alleles cc. (This means that the child has cystic fibrosis and has homozygous reccessive alleles.)

When they had children their alleles could also come together to make CC (homozygous dominant- this means that person doesn't carry an allele for cystic firbrosis and will never get it. This means that if that person had children with another person who has the alleles CC, their child wouldn't get it), or it could make a child with Cc alleles. The child with Cc alleles wouldn't get cystic fibrosis because the allele big C (dominant allele) over powers the allele small c (reccessive- the cystic fibrosis allele). Although this person doesn't have cystic fibrosis their children might because they carry the allele for cystic fibrosis, which is c.

Answer 4

Cystic Fibrosis can inherits, when he or she inherits two mutated CFTR genes one from each parent.

Answer 5

People or children usually inherit cystic fibrosi through a faulty gene.

Answer 6

They are born with it.