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pKa of drug can be determined from Handerson Hasselbatch equation., when conc. of salt become equal to acid i.e. at equivalence point when pH=pka then in H-H equn, pH=pka
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What is the pka value of Doxofylline?
Doxofylline Pka value is about 9.8.
What is PKa value of benzyl alcohol?
pKa = 15
PKa value of diethylmalonate?
It is around pKa=13
How do you know a drug is acidic or basic from pka value?
To be honest, sometimes it can be extremely difficult to choose which equation you should use depending on whether the solution is basic or acidic. But what I do know, is that when the pka is small then the solution is acidic, and when the pka is large then the solution is basic. "A weak acid has a pKa value in the approximate range −2 to 12 in water. Acids with a pKa value of less than about −2 are said to be strong acids. " this being said, its hard to distinguish whether a solution is acidic or basic since they both have such a wide range of pka values. but if you want just a general guideline then i would stick with the rule "high pka=basic, low pka=acidic
What is the pka value of ether?
The pka of a protonated ether (the conjugate acid) is about -3.5
Importance of pka value in drug absorption?
if Pka value is more for acidic drug,best side for absorption will be throughout the G.i.Tract.
What is the pka value of Doxofylline?
Doxofylline Pka value is about 9.8.
What is PKa value of benzyl alcohol?
pKa = 15
PKa value of diethylmalonate?
It is around pKa=13
How you can select buffer in hplc according to pka value?
By following + or - 2 pH to the pKa value
How do you know a drug is acidic or basic from pka value?
To be honest, sometimes it can be extremely difficult to choose which equation you should use depending on whether the solution is basic or acidic. But what I do know, is that when the pka is small then the solution is acidic, and when the pka is large then the solution is basic. "A weak acid has a pKa value in the approximate range −2 to 12 in water. Acids with a pKa value of less than about −2 are said to be strong acids. " this being said, its hard to distinguish whether a solution is acidic or basic since they both have such a wide range of pka values. but if you want just a general guideline then i would stick with the rule "high pka=basic, low pka=acidic
What is the pka value for NaCN?
NaCN doesn't really have a pKa. In water it becomes Na^+ and CN^-. The CN^- is a base so it will have a Kb and pKb. If you want the pKa of the conjugate acid (HCN), you can find that from 1x10^-14/Kb.
What is the pka value of ether?
The pka of a protonated ether (the conjugate acid) is about -3.5
A drug has pKa 5. at which PH it will be 99.9 percent ionized?
To determine at which pH a drug will be 99.9% ionized, we need to consider the Henderson-Hasselbalch equation. The pH at which a drug is 99.9% ionized can be estimated by finding the pH value that is one unit above the pKa of the drug. Therefore, in this case, the drug will be 99.9% ionized at a pH of 6.
What is pka value for sodium hydride?
The conjugate acid is Hydrogen (H2), the pKa of which is 35.
How you find out Pka value of organic compound for HPLC method develoment?
If you can't find it in the literature it can be determined experimentally by titration.
Is amphetamine a basic or acidic drug?
Amphetamines are a weakly basic drug with a pKa of about 9.8
