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Uranium itself is a naturally occurring metal, but seldom found as the native metal. The usual method of refining it from its oxides, (after reduction) is to convert into a chemical gas (uranium hexafluoride), and centrifuge this to obtain the particular isotope needed. Not a short process. UF6 is highly toxic and reactive.

Naturally, any uranium compound is radioactive, and dangerous to handle without particular precautions.

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