How do you replace the driver's side window motor in a 2000 Ford Expedition?

This is not an easy job. You need special tools to get the door panel off. I suggest you take it to the trim shop.

Actually you dont need special tools, all you have to do is remove 2 screws, one bolt and a long torx bolt.

Just remove the sail panel (covers the mirror bolts) and there is a screw behind it. pull out the switch panel and there is a screw behind it. pull the trim around the door handle and there is a bolt holding the door handle. and remove the light cover and there is a torx bolt in the light housing.

then lift straight up on the panel and once its loose, just unplug the light and it is off.

good luck