How do you replace the water pump on a 1996 Chevy Blazer S-10 4x4 4.3L V6?

This is a very difficult job for a do-it-yourselfer. Seriously, if you really don't know how to change the water pump on your Blazer then I'd recommend for you to take it to a qualified, reputable shop and have it done for you. If that's not feasible for whatever reasons and you basically need to do it yourself, then I'd say find a willing friend or relative to show you how and be there to help you do it. Find someone who is very knowledgable when it comes to working on automobiles. Find someone who has a real background in automotive mechanics. If you don't know anyone that can help you in this way then you can go to your local parts store or library and get a copy of the Chiltons manual for your specific vehicle. These are loads of help. They usually have very detailed step-by-step instructions along with a limited amount of pictures to help you along. They will even go into what other stuff you have to take off first and how to take it off. They will also tell you what tools you will need to complete the project. If for whatever reason all of the above solutions are not able to be done, then maybe you could attempt it yourself. But, make sure you take your time, and be very calm, and keep track of what you're are doing through every step. Make sure to use the right tools for the job. You won't believe the extra headache you'll cause yourself if you round a bolt head from using the wrong socket, or vise grips. Also find some masking tape and label all wires, hoses, nuts, bolts, that you take off and their attaching places if you have to. If you do that I see no reason as to why you could not complete this yourself. A lot of novices have followed my walkthrough with positive results. See the Related Link for "1996 and Up Water Pump Replacement Procedure" to the right for the walkthrough with pictures.