How do you reply to 'What are your strengths and weaknesses' on an interview?

That is always a difficult question to answer in an interview without sounding full of yourself. As a supervisor, when I interview a person and ask that question what I am looking for is, "What are you good at?" and "What do you need to work on?" When someone only gives me strengths, their application goes to the bottom of the pile.

Be honest; tell the interviewer your strengths and weaknesses. Don't down yourself in stating your weaknesses either. They are what they are and there is always room for improvement there.