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How does LSD affect the brain and neurochemistry?

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2010-07-22 23:04:50
2010-07-22 23:04:50

No one knows definitively. The best scientific explanation that I've seen is that LSD triggers a cascading release of serotonin and other neurotransmitters in the brain, resulting in heightened neural activity which the conscious mind then struggles to interpret sensibly (leading to altered perception, affect, and hallucinations).

An interesting side note, only around 3/4 of a percent of lysergic acids (LSA, ALD, LSD, ect.) actually cross the blood-brain barrier.

Some theorize LSD blocks serotonin receptors, while others believe LSD agonizes them. The most widely accepted theory is that LSD does both; blocking certain receptors and agonizing others. In a "layman" sense, the blockage and excitement of these receptors causes the brain to "skip a beat", and have to learn to regulate it's serotonin levels. While this is happening, the brain seems as if it is "re-wiring" itself, causing the user to face different levels of emotions and states of psychosis as the "trip" progresses. Depending on the mental status and environmental surroundings of the user, an LSD experience can either cause prolonged psychosis or a heightened sense of self awareness. How long these effects stay with the user depends on the intensity of the trip and how prepared the user was to the effects at the time of use.

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LSD effects the entire brain, and actually increases total brain activity. Effects of LSD are perceived most strongly in the frontal lobe, visual and audial cortices (located in the front, back, and side of the brain respectively).


It reacts with receptors which in turn affect your perception, but does not damage or kill any brain cells or permanently affect its structure


The brain. LSD get's it effects by binding to Serotonin receptors in the brain.


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No it doesn't. If that happens (whether you are on LSD or not) there is a serious issue.


All abused drugs will kill your brain cells.


No, technically LSD does not affect your subconscious motor skills. LSD will however impair your ability to react to a stimulus with motor skills.


LSD users can behave violently, which may harm the baby if the mother hurts herself.Use during pregnancy can lead to low birth weight, poor muscle control, brain damage, & withdrawal syndrome if used frequently.


Kenneth Allan Caldwell Elliott has written: 'Neurochemistry' -- subject(s): Neurochemistry


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It simply does not affect the preformance, it just might help the preformance


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All I know is that you get a trip with no kids.


LSD can affect anyone, so yes it would affect people with epilepsy. How it affects them would depend on all sorts of factors, like how much they take and the type and severity of epilepsy they have and any other conditions they may have.


LSD mainly affects the Cerebral Cortex. LSD is a serotonin receptor agonist and much of its hallucinogenic effects are thought to result from binding to the 5-HT2A serotonin receptor in particular. LSD also affects all subtypes of dopamine receptor and all subtypes of adrenoreceptor.



yes it does affect the brain in many different ways


Most drugs are similar in structure to neurotransmitters, and mimic their effect in the brain. Others will inhibit neuro transmitters as well. Alcohol -> GABA LSD -> Serotonin Cocain -> adrenalin morphine - endorphine etc...


Syphilis can affect the brain.Syphilis will eventually affect the brain.Syphilis causes brain deterioration in its late stages.



Well it created a generation of hippies, which took over the 70s



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