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This is an incredibly broad question. The basic theory is that many drugs force there to be an excess of serotonin in the synapse of a neuron, by either stopping the re-uptake of it (antidepressants) or by other complex actions (amphetamines). The addicts nervous system begins to take note of this and not produce/release as much serotonin, this leads to a state of low level endogenous serotonin production, thus leading to withdrawal and craving. By taking said drug again, the patient is able to feel normal again. It should be noted that this is an extremely simple explanation of this, and that addiction is a VERY complex topic.. Dr. Dan

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16y ago
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13y ago

I'm not a doctor but from what I understand they have a kind of "tug of war" relationship (dopamine and serotonin , Adderall works primarily on dopamine). One (dopamine) stimulates, the other (serotonin) inhibits or"calms". I believe adderall may initially boost serotonin a bit along with dopamine and norepinephrine but eventially depletes it.(Hence the real irritability on the comedown)SSRI's can reduce this effect a bit.Anyway I'm researching the same thing so that's the best I could come up with so far. Good luck on your recovery.

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13y ago

Alcohol raises serotonin levels in the short term, but repeated usage lowers serotonin levels, because alcohol causes the brain to eventually run out of serotonin.

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Q: How does alcohol affect serotonin in the brain?
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