295-337 mi.
It all depends on what route you take.
5 hours
In a straight line, Orlando, Florida to Fort Myers, Florida would be about 135 miles.
If you are going to Englewood, FL in Duval County (Jacksonville area) its about 323 miles. There is a second Englewood in Sarasota County just North of Ft Myers that is about 50 miles away.
It is 126 miles (2 hours 5 minutes) from Tampa, Florida to Fort Myers, Florida if you travel via I-75 South.
How far is West Palm beach from Fort Myers 125.56 miles appox 2.5 hr drive time
The shortest driving distance is 311 miles.
It is 56.69 miles according to MapQuest.
About 135 miles driving distance.
It is 126.00 miles according to MapQuest.
It is 126 miles according to MapQuest.
About 750 miles.
It is 295 miles according to Google Maps.