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Tylenol (acetaminophen) will stay in your system up to 48 hours if you take therapeutic doses of around 1000mg. However, this depends on your liver and metabolites.
The half life is around 4-8 hours, so if you're worried about testing positive for it and want to be completely on the safe side, err to the side of 48 hours.
Wiki User
∙ 15y ago
Wiki User
∙ 9y agoTylenol does not stay in your body more than 8 or 9 hours at a time. If you are taking Tylenol PM regularly to fall asleep, you should consult a sleep specialist or doctor.
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