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Answered 2014-03-04 19:10:09

The average elimination half-life is the period of time it takes for a substance undergoing decay to decrease by half. In adults for dextroamphetamine and levoamphetamine is 10 hours and 13 hours respectively. So basically it means in 20 to 26 hours. I would give it at least 48 hours.

A drug test can tell the difference if sent to a lab other wise the test will show up as just an unknown amphetamine. So if you're going to be tested by probation or for court they will tell the difference because it will be sent to a lab for further testing, as to where a home test (that is not being sent out) or job will not specify which amphetamine it is.

Specifically, Adderall XR consists of the following amphetamine compounds in equal proportions: dextroamphetamine saccharate, dextroamphetamine sulfate, racemic amphetamine aspartate monohydrate, and racemic amphetamine sulfate.

Breakdown rates are affected by many factors including urinary and stomach pH, weight, gender, other medications being taken, and age. Alkalinity increases bioavailability and acidity causes the drug to be excreted sooner.

Manufacturers claim that the mixture of salts in Adderall XR makes its effects smoother (that is, makes softer highs and lows). The mixture of salts and their ratios are as follows:

  • 1/4 dextroamphetamine saccharate
  • 1/4 dextroamphetamine sulfate
  • 1/4 (racemic dextro/levo-)amphetamine aspartate monohydrate
  • 1/4 (racemic dextro/levo-)amphetamine sulfate

These four salts are metabolized at different rates and possess diverse half lives (citation needed), therefore resulting in a less dramatic onset and termination of therapeutic action, as compared to single-salt amphetamine preparations (citation needed)

Adderall is available as an instant release ("IR") as well as an extended release ("XR") drug

The immediate release formulation is indecated for use in Attention Deficit Hyperactivity Disorder (ADHD) and narcolepsy, while the XR formulation is approved for use only with ADHD. In the United States, Adderall is a Schedule II drug under the Controlled Substance Act due to having significant abuse and addiction potential.

The difference between the two is this: levomethamphetamine is approximately 28% of the drug Adderall (racemic amphetamine salt mixture), while 72% of the drug is dextroamphetamine.

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