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For me, the really bad part only lasted about 36 - 48 hours, but the lingering need and rebound headaches continue for me (it's been 10 days). But I did not think I was going to survive the first 24 hours, it is that bad.

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15y ago
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8y ago

Since you can take up to 8 of them in a day, probably the drug is out of your system within a day. However, if you plan on having surgery, you should check with your physician to see if they would like you to stop taking it up to a week or so before.

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14y ago

According to AskDocWeb the half-life of Excedrin is 2 - 4 hours so it leaves your system completely in less than a day.

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15y ago

Excedrin (or Excedrin Migraine) takes about 4 hours to be depleted in the system in someone who is healthy. The aspirin component takes slightly less time than the acetaminophen and caffeine.

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14y ago

For me, it takes fifteen minutes to a half an hour if I can catch the headache right away. Hope you feel better soon!

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Q: How long does it take for Excedrin migraine to be depleted from your system?
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Can you take methadone and excedrin migraine together?

Yes, you can take methadone and Excedrin Migraine together. Methadone is a synthetic opiate medication used to treat pain and also combat the withdrawal symptoms of heroin. It is used to treat heroin withdrawal because it puts an opiate in the system of the patient, but does not provide the euphoric rush that heroin does. Excedrin Migraine contains acetaminophen (Tylenol), aspirin (an NSAID), and caffeine. None of the ingredients in Excedrin Migraine should interfere with methadone use.


How long does it take for excedrin to get out of your system in order to get a clean urine test?

Excedrin doesn't linger in your system for more than 2 days or so. One day and it should be cleanly gone.


Can you take excedrin migraine 4 hours after taking ibuprofen?

The short answer is yes. Ibuprofen and Aspirin are both drugs that are non-steroidal anti-inflammatory drugs (NSAIDS). If you took a standard dose of aspirin for pain (325-650mg) and were still experiencing some discomfort you can take so ibuprofen. I would recommend taking it with food to reduce stomach upset.


When will Excedrin be back on the shelf?

For the most up-to-date information on Excedrin's availability, I recommend checking with retailers or Excedrin's official website for announcements regarding restocking and availability. Generally, the timing of when Excedrin will be back on the shelf can vary due to factors like production, distribution, and demand.


Is Migraine curable?

Yes.May need to take medicine for long time...


How long until excedrine migraine will be back on the shelves?

Excedrine Migraine is now available for purchase again in the United States. For appropriate diagnosis, treatment and management of Migraine, please seek the help of a board certified Migraine and headache specialist who has had additional training and experience in headache medicine.


Will exedrin migraine help a migraine?

It can potentially help. It contains acetaminophen, aspirin, and "Therapeutically Active Caffeine". These ingredients, when combined, can help to relieve a migraine. The effectiveness of Excedrin Migraine, or any other pain reliever for that matter, depends on the individual: what works for one person may not help another. It also depends on when you take it, since waiting too long to take any kind of pain medication will reduce its overall effectiveness and can increase the amount of time it takes to work.It's important to note that you should never exceed the recommended dosage on over-the-counter or prescription medicine unless your doctor has stated otherwise. Also, overuse of pain relievers can lead to what's referred to as "rebound headaches", which will not be helped by any kind of medication.


How long does it take to charge segways?

6 hrs. if the battery is fully depleted


How long do migraine meds stay in the system?

How long your medicine stays in your system is completely dependent upon the medication and your personal body system. Medications are measured by something called their half life. This means the length of time until half the medicine has left the body. The longer the half life, the longer time the medicine will stay in your system. Each medicine has a different half life.


Can you take Excedrin PM for a headache at 12 am if you took Phentermine 12 hours earlier?

Yes. Excedrin PM (unlike its cousins - the other Excedrins) does not contain caffeine. It contains diphenhydramine (Benadryl) to help you fall asleep. So it will not react with Phentermine, which is a stimulant. Phentermine stays in the system a long time. 16-31 hours is its half-life (which means it might take more than full day to work out of your system). So be careful in the daytime with other stimulants.


For how long does excedrin relief pain from your body?

Excedrin (as well as Excedrin Migraine which contains the same ingredients), contains Acetaminophen (Tylenol), Aspirin, and Caffeine. Acetaminophen works to relieve pain and has a half-life of 2-4 hours. So, anywhere from 4-8 hours the acetaminophen will be completely gone from your body. Aspirin works by blocking pain signals before they get to the brain, also by reducing inflammation (where much of migraine pain is an inflammatory response - this is especially important). Its half-life (for the normal dosage of Excedrin) would be about 3.1-3.2 hours. So, at about 6 hours all aspirin would be gone from your body. Caffeine works both by increasing the rate of absorption of the medication and by working as a vasocontrictor on blood vessels that are dilated due to inflammation. Taking two Excedrin is about the same as drinking a cup of coffee. The half-life of caffeine is about 5 hours. The directions for Excedrin say to take 2 tablets every 6 hours. This is both because they don't want you overdosing on the medication and because at about 6 hours the pain relieving effects will be wearing off from all three components. If you are taking over-the-counter medications for your headaches and are finding they are doing little to nothing for your pain, see your doctor. And please read the labels of any other medications your are taking to make sure they do not contain an NSAID (like ibuprofen - which is Motrin, Advil) or Acetaminophen (which is in every form of Tylenol and in some cold medications as well).


How long does migraine last?

They usually only last a day or two. A Migraine that lasts more than 3 days is called Status Migrainousus and a reason to see a doctor asap. Migraineous stroke is rare, but becomes much more likely the longer the Migraine attack goes on. For best results, see a headache specialist who has had extra training in diagnosing and treating these types of disorders. There are many different types of headaches, and this may not be a Migraine at all.