The driving distance between Des Moines, IA and Orlando, FL is approximately 1335 miles. The driving time would be approximately 23 hours if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work, border crossings and rush hour traffic in urban areas.)
24 hours
Just about two hours.
It depends on the speed at which you drive.
4
as long as it takes
About 3 hours for the 180 mile drive.
Assuming you mean Orlando, FL the answer is about 11hours.
About 53 minutes
Check Mapquest.com
About a three hour drive on the highways.
12 hours
19