That depends where you're going. Phoenix to Orlando is 32 hours, (2150 miles) Yuma to Miami is 37 (2500 miles)
First you would need a Bridge from Florida into Puerto Rico. You can drive from Arizona to Florida.
It is 2,247 miles according to Google Maps.
It is an estimated 36 hour drive according to Google Maps.
MapQuest estimates the driving time as 27 hours and 41 minutes.
1866 miles -- See Sources and related links for mileage calculator.
Google Maps estimates the drvng time as 39 hours.
MapQuest estimates the driving time as 30 hours and 2 minutes.
MapQuest gives that trip a driving time of 31 hours and 35 minutes.
Google Maps estimates the driving time as 26 hours/
MapQuest estimates the driving time as 31 hours and 21 minutes.
12 Hours
Not long if you are in Blythe, California.