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Did this in stages by Greyhound bus - def wouldn't recommend you do it in 1 stretch..... LA to Vegas is about 5hrs, then on to Denver is a further 16 hours or so, then 18 hrs to St Louis? Was a couple of yrs ago but gives you a general idea! Not the most comfortable trip!!

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12y ago
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Q: How long would it take to go from California to Missouri by bus?
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