The shortest driving distance is 49 miles.
Maybe about 60 miles, because it takes about an hour to get to San Francisco from there.
Napa Valley, CA is 788 sq miles (2,041 km²).
163 miles
75 miles
438 miles
766.9
The Napa Valley is located about an hour north of San Francisco. The Valley is 30 miles long and ranges from 1 to 5 miles in width. This is one of the top wine producing regions of the world and attracts many visitors. There are more than 200 wineries with tasting rooms where you can visit and sample the wines. Many provide tours.
84.2
About 55 miles on the I-580/80 E.
Napa is inside the Napa Valley.
Google maps, 61.8 miles from SFO to NAPA
143 road miles.