126 miles
Tampa to Key Largo is about 300 miles. Tampa to Key West is about 400 miles.
97 miles
289 miles taking this route:Take Florida's TURNPIKE (toll) SOUTH, from Orlando, to U.S. 1 SOUTH to KEY WEST at where Florida's TURNPIKE - ENDS in Homestead.Take U.S. 1 SOUTH to Key Largo.
Venice to Key Largo is 243 miles. Venice to Key West is 358 miles. Your exact distance is probably somewhere in there.
The answer to such a question depends on your ultimate destination in the Florida Keys. For instance, depending on the exact route, the distance between Tampa and, say, Key Largo (the northernmost island in the Florida Keys) can range from 295 to 325 miles. Meanwhile, the distance between Tampa and Key West (which is located at the southern end of the Florida Keys) can range from 400 to 425 miles.
The Keys are 120 miles long. Hilton Head to Key West is 674 miles.
The Keys are 100 miles long. Key Largo is about 340 miles from Palm Coast. Key West is 440 miles.
Key Largo, Marathon, Key West,
It is 97.6 miles according to Google Maps.
About 360 Miles
166 miles
About 233 miles