If you are on Seroquel up to 300 mg at night klonopin 0.5 bid ativan 0.5 prn and Cymbalta 90 mg qd should you be concerned with interactions or addictions?

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September 12, 2011 9:44PM

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Seroquel (quetiapine), Cymbalta (duloxetine), Klonopin

(clonazepam), and Ativan (lorazepam) are typically safe to take

together as long as the medications are ALL prescribed by the

same doctor, and you use them as prescribed. If they have been

prescribed by different doctors, you should consult with your

primary physician regarding all the medications you are taking from

all sources. She can advise you. So can a pharmacist.

The significant interaction is that the medication combination

can have additive effects causing more sleepiness and increased CNS

depression. In some cases people have a very difficult time

functioning because they are so tired. Those side effects would

occur almost immediately so if you are tolerating the medication

now that should not be an issue.

Also if you have a personal or family history of diabetes or

other major metabolic problems then there is an increased risk

(although it is rare) for developing diabetes, even more uncommon

potential problems are neuroleptic malignant syndrome or serotonin

syndrome. Using both Seroquel and Cymbalta do increase these risks

however the majority of the risk comes from Seroquel. Seroquel can

also cause tardive dyskinesia, a serious movement disorder that

typically lasts for years (and often for life). However most

people, especially those with bipolar or a psychotic disorder don't

have any of these rare reactions.

Overall the medications are not strange at all. Granted it is a

very sedating combination and that is the primary thing you need to

be aware of.

It may also be worth talking with your doctor if you find you

are tired a lot or you are having other side effects.

As for addiction you do take two controlled substances, Klonopin

and Ativan. However neither drug is significantly addictive.

Benzodiazepines, the class of drugs Klonopin and Ativan are in,

have been shown to have a moderate abuse liability in animal and

human testing. It is important to avoid increasing the dose of

either drug, especially the Klonopin since you take it every day.

As long as you do not start dose escalation (taking more without

doctor approval) addiction is rare. In fact 80-90% of

benzodiazepine addicts have a separate active addiction to

something like heroin, alcohol, or cocaine and they use the

benzodiazepines to augment other drugs or help them "come down" of

off stimulants.

"Answer" id="Answer">Answer

"IIII:" id="IIII:">IIII:

Yes, you need to be careful with Alcohol for sure. I would then

susspect addictions too. I am on Seroquel and have had a bad

reaction with Alcohol.My doctor always says to me,"One should never

drink alcohol with Seroquel. The Pharmacist,tells me it is not

advisable and is dangerous.

The pharmacist said though, if you should try Alcohol, drink

very little at first and see how you react. So I did try it. For me

it makes me tense instead of relaxed.It makes me feel like I have

taken more Seroquel. On the very first beer, I felt increase in

muscle spasms of my tongue and back. My heart raced 5 hrs later and

I felt like dying. I try'd a sip of a stronger cocktail once with

Vodka and emiediately had one of the worst headaches you could


I have also researched and found interactions with grapefruit

juice and Seroquel. Drugs that sedate you will make you way more

sedated. You should check even over the counter meds and

prescriptions with your pharmacist. Even some cold remidies may

cause a problem.

Remember everyone is different. I had a reaction with Seroquel

and Celexa.

I think a little Ativan should be fine, but be careful when

driving and other tasks with needed mental and motor functions.

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