Is it serious if your car makes noise during driving?

That depends... What does the noise sound like? Where does it seems to come from? Does it only happen at certain speeds? When shifting gears? When braking? When turning? When accelerating? Is there a vibration with the noise? This question can not be honestly answer without being a lot more descriptive. My car is making a clicking noise when accelerating...it sounds like a can of marbles...what can be causing this to happen. It has been doing it for 4 years and no one seems to ever know where it is coming from. Could it be from the crankshaft? answer mabe the cam shaft or the lifters not the crankshaft more likely to be a leak around the exhaust manifold