Yes! Allways use caution when working with fuel! If the car is "hot" there may be pressure. Also the system may be gravity feed and gasoline may flow out, and if you just turned on the ignition, it will have full pressure in the line. It will allways have some fuel pressure.
Before changing the fuel filter locate the fuse or relay for the fuel pump and disconnect it, then start the truck until it dies. This will minimize pressure in the line.
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