Sasuke doesnt have a sister.
No sasuke doesn't kill Tsunade but Danzo almost killed her.
Tsunade is made Hokage Before Sasuke leaves. She's the one who sent Shikamru and the team of Genin after him.
To answer your question. No Uchiha Sasuke does not kill Tsunade-Sama.
Chapter 350
~Spoilers~Sasuke did not kill Tsunade Hime.She isn't even dead, shes in a coma caused by using up the chakra stored in her forehead in the battle against Pain.
The episode where Tsunade acceptes the Hokage title.
ep.211 lady tsunade sends naruto on a mission to kill madara uchiha <tobi> and then the akatsuki went to kill tsunade she dies leaving naruto as hokage but just then sasuke shows up with the taka and naruto puts them in ninja jail . Sasuke claims to know a jutsu to bring people back to life they take him out of ninja jail.He brings back tsunade,jiraya and itachi.then sasuke and itachi become legendary sannin
Rock Lee was healed by Lady Tsunade in episode 100. The operation was successful and Rock Lee was able to walk again.
Team 7 was trained by three Sanins: Jiraiya, Tsunade and Orochimaru. Naruto is trained by Jiraiya, Sasuke by Orochimaru and Sakura by Tsunade.
lol the question says what episode does jiraiya and tsunade fight orochimaru, and its 52 not 133, 133 when naruto and sasuke fought
to get tsunade in naruto arena, you are first going to need sakura and shizune. you should win 5 battles in a row with them both and win seven battles against naruto, kakashi, sasuke and kabuto with either sakura or shizune.
You have to complete all quests in konoha first then you will have to talk to a guy in konoha gate and talk to tsunade after. then go to orochimaro hideout and search for a blue aura. after that sasuke rpg mode should be unlocked