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It is perfectly safe to take Selective Serotonin Re-uptake Inhibitors with hydrocodone. They do not interact or effect one another. SSRI's only affect the serotonin levels in your brain, hydrocodone blocks nerve receptors, which helps with pain. So any SSRI anti-depressant is safe to take with hydrocodone.

Edit: I wouldn't say it is perfectly safe. Serotonin Syndrome can happen and isn't something you just brush off

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Q: Mix hydrocodone and SSRI
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