The S strain produces a capsule but the R strain does not
s strain is capsulated while r is not.
He showed that the DNA from strain S cells could transform strain R cells.
A very important characteristic about bacteria actually created live S-strain to exist in the dead injected mouse. Bacteria is competent, in biological terms, meaning that cells can take up "naked" DNA from it's environment. Knowing that fact, when the heat-killed S-strain pneumoccus mixed with the live R-strain, the R-strain took in the DNA, therefore inheriting the deadly coating of the S-strain. So the R became S, and killed the mouse.
S Strain ---> inject into mice ---> Mice Die R Strain ---> inject into mice ---> Mice Live Griffith was able to kill bacteria by heating them. He observed that heat-killed S Strain bacteria injected into mice did not kill them. When he S Strain (heat Killed) ---> Injected into mice ---> Mice Live S Strain ( heat Killed) + R Strain (Live) ---> Injected into mice ---> Mice Die
Because It's very dangerous
Streptococcus pneumoniae bacteria is found in two types: a type III-S (smooth) and type II-R (rough) strain. The smooth strain covers itself with a polysaccharide capsule that protects it from the host's immune system, resulting in the death of the host, while the II-R strain doesn't have that protective capsule and is defeated by the host's immune system.The smooth type has a "coat" that prevents it from attacks from the host's immune system and it is very virulent.
Griffith hypothesized that a chemical component from the virulent S cells had somehow transformed the R cells into the more virulent S form.
Frederick Griffith was a British bacteriologist. In January 1928, he reported what is now known as Griffith's Experiment, the first widely accepted demonstrations of bacterial transformation, whereby a bacterium distinctly changes its form and function.
t He then took the R strain (rough strain) and injected it into the mice and found that they did not contract the pneumonia illness and survived the insertion of the strain
G. R. Cowper has written: 'Strain-hardening and strain-rate effects'
the conversion of R forms of one type into S forms of a different type
the conversion of R forms of one type into S forms of a different type
Mixing a heat-killed pathogenic strain of bacteria with a living nonpathogenic strain can convert some of the living cells into the pathogenic form.