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The major target of aldosterone is the distal tubule of the kidney, where it stimulates exchange of sodium and potassium. Three primary physiologic effects of aldosterone result:
- Increased resorption of sodium: sodium loss in urine is decreased under aldosterone stimulation.
- Increased resorption of water, with consequent expansion of extracellular fluid volume. This is an osmotic effect directly related to increased resorption of sodium.
- Increased renal excretion of potassium.
Knowing these effects should quickly suggest the cellular mechanism of action this hormone. Aldosterone stimulates transcription of the gene encoding the sodium-potassium ATPase, leading to increased numbers of "sodium pumps" in the basolateral membranes of tubular epithelial cells. Aldosterone also stimulates expression of a sodium channel which facilitates uptake of sodium from the tubular lumen.
Wiki User
∙ 9y ago
Wiki User
∙ 14y agoIncreased sodium reabsorption, and since water follows sodium it also increases water reabsorption in kidneys.
Wiki User
∙ 12y agoAldosterone: A hormone made by the outer portion (cortex) of the adrenal gland that regulates the balance of salt and water in the body.
Wiki User
∙ 9y agoIt increase the reabsorption of Na+.So blood pressure is increased.
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What is the purpose of an aldosterone assay?
Aldosterone measurement is useful in detecting a condition called aldosteronism, which is caused by excess secretion of the hormone from the adrenal glands. There are two types of aldosteronism: primary and secondary.
What is the roleof aldosterone?
Aldosterone will cause Na+ to be absorbed from a filtrate
What is the role of aldosterone?
Aldosterone promotes water retention and reduces urine volume
How to increase aldosterone?
Aldosterone helps to indirectly regulate blood levels. A low sodium diet is a way to increase aldosterone in the body.
How does dehydration affect aldosterone secretions?
It decreases the affect of aldosterone secretion.
How does aldosterone get to the kidneys?
Aldosterone is a hormone, so it gets to the kidneys via the blood stream.
Which area is sensitive to aldosterone?
Aldosterone is sensitive to a few different things. The main thing it is sensitive to is the kidneys.
What happens when Aldosterone increases?
Aldosterone causes sodium to be retained and potassium to be excreted and blood pressure to rise.
What is the major mineralocorticoid?
Aldosterone
What is the abbreviation of aldosterone?
ADT
Is aldosterone released by humoral factors?
Aldosterone is regulated by negative feedback system except in cases of dehydration in which high sodium levels stimulate more production of aldosterone. Normally negative feedback regulates production.
What is the purpose of an assay?
Aldosterone measurement is useful in detecting a condition called aldosteronism, which is caused by excess secretion of the hormone from the adrenal glands. There are two types of aldosteronism: primary and secondary.
