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Healthy cells become cancer cells by means of genetic alteration, and that alteration can be caused by a variety of things including viruses, radiation including ultraviolet radiation present in sunlight, toxic chemicals, or even physical injury on a microscopic scale that can be caused by such things as asbestos fibers.

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13y ago
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8y ago

There are many causes like:

  • radiation, even radiotherapy for cancer can cause another types of cancer
  • chemicals like tobacco, asbestos, and even some anticancer drugs can cause cancer.
  • viruses, most of them are sexually transmitted.
  • bacteria (helicobacter pylori) which is associated with peptic ulcer.
  • the risk of certain types of cancer can be increased by inheritance.

According to World Health Organization (WHO), common risk factors for cancer include:

  • Tobacco use
  • Alcohol use
  • Obesity
  • Dietary factors, including insufficient fruit and vegetable intake
  • Physical inactivity
  • Chronic infections from helicobacter pylori, hepatitis B virus (HBV), hepatitis C virus (HCV) and some types of human papilloma virus (HPV)
  • Environmental and occupational risks including ionizing and non-ionizing radiation

Cancers are a broad group of diseases and accordingly have a wide range of causes. Each cancer is different according to its Biology and pathophysiology. All animals and even plants are susceptible to cancers. The body is made up of trillions of living cells. These cells grow, divide, and die in an orderly fashion. This process is tightly regulated and is controlled by the DNA machinery within the cell. In a baby or a child normal cells divide rapidly to allow for growth. After the person becomes an adult, most cells divide only to replace worn-out or dying cells or to repair injuries. When cells of the body at a particular site start to grow out of control, they may become cancerous. Cancer cell growth is different from normal cell growth. Instead of dying, cancer cells continue to grow and form new, abnormal cells. In addition, these cells can also invade other tissues. This is a property that normal cells do not possess. Cancer cells originate from normal cells when their DNA (deoxyribonucleic acid) or blue prints within the cell nucleus is damaged. DNA is in every cell and it directs all the cell's actions, growth, death, protein synthesis etc. when DNA is damaged in a normal cell the cell either repairs the damage or the cell dies. Normally, the body safeguards against cancer via numerous methods, such as: apoptosis or a process by which abnormal cells die on their own accord, helper molecules (some DNA polymerases), possibly senescence or aging, etc. In cancer cells, the damaged DNA is not repaired, and the cell does not die. Instead it gives rise to more such abnormal cells with abnormal DNA. These new cells all have the same defective DNA of the original cancer cell. DNA damage may be inherited from parents or may be a spontaneous problem that occurs during the lifetime of a person. This is called a mutation. DNA damage may also be triggered by exposure to certain environmental toxins such as those present in cigarette smoke. There are, however, multiple factors that may cause cancer and it is difficult to pin point an exact cause.

Here is a list of items that are believed to cause cancer, according to news shows or magazines. These include items that say on the labels that the products may cause cancer (usually the labels will say 'caution: product known to cause cancer in lab rats' or something to that effect):

  • tobacco
  • second-hand smoke
  • incense
  • laundry detergent
  • jewelry cleaner
  • household poisons and cleaning solutions
  • pollutants in the air
  • microwaves
  • cell phones
  • red meats
  • paint
  • lead products used in makeup

This list could go on and on. Unfortunately no one really knows 100% for sure.

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8y ago

Chemical carcinogens

Several chemicals and environmental toxins are responsible for changes in normal cellular DNA. Substances that cause DNA mutations are known as mutagens, and mutagens that cause cancers are known as carcinogens.

Particular substances have been linked to specific types of cancer. Tobacco smoking is associated with many forms of cancer, and causes 90% of lung cancer. Similarly, prolonged exposure to asbestos fibers is associated with mesothelioma.

Tobacco is also related to other cancers such as lung, larynx, head, neck, stomach, bladder, kidney, oesophagus and pancreas as it contains other known carcinogens, including nitrosamines and polycyclic aromatic hydrocarbons.

Ionizing radiations

Radiations due to radon gas and prolonged exposure to ultraviolet radiation from the sun can lead to melanoma and other skin malignancies. Radiation therapy given for one type of cancer may also cause another type of cancer. For example, those who receive chest radiation therapy for lymphomas may later develop breast cancer.

Viral and bacterial infections

Some cancers can be caused by infections with pathogens. Notable among these include liver cancers due to Hepatitic B and C infections; Cervical cancer due to infections with Human Papilloma virus (HPV); Epstein Barr virus causing Burkitt's lymphoma and gastric or stomach cancer due to Helicobacter pylori infection.

Genetic or inherited cancers

Common examples are inherited breast cancer and ovarian cancer genes including BRCA1 and 2. Li-Fraumeni syndrome includes defects in the p53 gene that leads to bone cancers, breast cancers, soft tissue sarcomas, brain cancers etc. Those with Down's syndrome are known to develop malignancies such as leukemia and testicular cancer.

Hormonal changes

Notable among these are changes in the female hormone levels estrogen. Excess estrogen promotes uterine cancer.

Immune system dysfunction

Impaired immunity including HIV infection leads to several cancers including Kaposi's sarcoma, non-Hodgkin's lymphoma, and HPV-associated malignancies such as anal cancer and cervical cancer.
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11y ago

Sunlight (UV rays), radioactivity, smoking, pollution, certain pesticides used in the preservation of vegetables, asbestos, and chemical compounds that are classified as carcinogens.

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8y ago

Risk factors for cancer

According to World Health Organization (WHO), common risk factors for cancer include:

· Tobacco use

· Alcohol use

· Overweight and obesity

· Dietary factors, including insufficient fruit and vegetable intake

· Physical inactivity

· Chronic infections from helicobacter pylori, hepatitis B virus (HBV), hepatitis C virus (HCV) and some types of human papilloma virus (HPV)

· Environmental and occupational risks including ionizing and non-ionizing radiation

Agents that may cause cancer include:

Chemical carcinogens

Several chemicals and environmental toxins are responsible for changes in normal cellular DNA. Substances that cause DNA mutations are known as mutagens, and mutagens that cause cancers are known as carcinogens.

Particular substances have been linked to specific types of cancer. Tobacco smoking is associated with many forms of cancer, and causes 90% of lung cancer. Similarly, prolonged exposure to asbestos fibers is associated with mesothelioma.

Tobacco is also related to other cancers such as lung, larynx, head, neck, stomach, bladder, kidney, oesophagus and pancreas as it contains other known carcinogens, including nitrosamines and polycyclic aromatic hydrocarbons.

Ionizing radiations

Radiations due to radon gas and prolonged exposure to ultraviolet radiation from the sun can lead to melanoma and other skin malignancies. Radiation therapy given for one type of cancer may also cause another type of cancer. For example, those who receive chest radiation therapy for lymphomas may later develop Breast cancer.

Viral and bacterial infections

Some cancers can be caused by infections with pathogens. Notable among these include liver cancers due to Hepatitic B and C infections; cervical cancer due to infections with Human Papilloma virus (HPV); Epstein Barr virus causing Burkitt's lymphoma and gastric or stomach cancer due to Helicobacter pylori infection.

Genetic or inherited cancers

Common examples are inherited breast cancer and ovarian cancer genes including BRCA1 and 2. Li-Fraumeni syndrome includes defects in the p53 gene that leads to bone cancers, breast cancers, soft tissue sarcomas, brain cancers etc. Those with Down's syndrome are known to develop malignancies such as leukemia and testicular cancer.

Hormonal changes

Notable among these are changes in the female hormone levels estrogen. Excess estrogen promotes uterine cancer.

Immune system dysfunction

Impaired immunity including HIV infection leads to several cancers including Kaposi's sarcoma, non-Hodgkin's lymphoma, and HPV-associated malignancies such as anal cancer and cervical cancer.

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16y ago

Most cancers are hereditary desieses but some cancers such as skin cancer and Lung cancer can be caused by the sun or by smoking.

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12y ago

smoking that i think is for lung cancer though. That's all i no!

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11y ago

smoking

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Q: What are the causes of cancer?
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