One of America's great highways Interstate-80 streches from Wyoming to Iowa. Nebraska is a state with several major highways. A few major highways in Nebraska are I-80, Cornhusker Highway, and U.S. Highway 6.
Major highways in the state of South Dakota include Interstate 90, running east and west across the state and Interstate 29, running north and south. Other major highways include: US Highways 12, 14, 16, 81, 83, 85, 212, 281, and 385
The major north/south highways in Illinois are IL55 (Chicago to St. Louis MO), IL90 (Chicago to Beloit WI) and IL57 (Chicago to Kentucky. The major east/west highways in Illinois are IL80 and IL88, both of which will take you to Iowa.