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Atropine does not only block nicotinic receptors but also acetylcholine at muscarinic receptors
Two types, nicotinic and muscarinic
sodium
The 2 divisions of the autonomic nervous system (sympathetic and parasympathetic) both have 2 areas where neurotransmitter is released. ?They have ganglionic synapses in the periphery wherein neurotransmitter is released and have synapses on the target organs wherein neurotransmitter is released. ?So this means there is preganglionic and postganglionic release of neurotransmitter.Sympathetic preganglionic neurotransmitter is Acetylcholine. ?Acetylcholine affects muscarinic receptors here.Sympathetic postganglionic neurotransmitter is Norepinephrine. ?Norepinephrine affects alpha or beta receptors here. ?Parasympathetic preganglionic neurotransmitter is Acetylcholine. ? Acetylcholine affects muscarinic receptors here.Parasympathetic postganglionic neurotransmitter is Acetylcholine. ?In this case Acetylcholine affects muscarinic receptors.?Sympathetic neurons are considered to be adrenergic & sympathetic neurons are considered to be cholinergic.
Alpha-Motor neurons release the neurotransmitter acetylcholine at a synapse called the neuromuscular junction. When the acetylcholine binds to acetylcholine receptors on the muscle fiber, an action potential is propagated along the muscle fiber in both directions.
nicotinic acetylcholine receptors (nAChR, also known as "ionotropic" acetylcholine receptors) are particularly responsive to nicotinemuscarinic acetylcholine receptors (mAChR, also known as "metabotropic" acetylcholine receptors) are particularly responsive to muscarine.Nicotinic and muscarinic are two main kinds of "cholinergic" receptors.
ACH receptors can be defined as an integral membrane protein that responds to the binding of acetylcholine, a neuoyansmitter. Two example are nicotinic acetyl line receptors and muscarinic acetylcholine receptors. .
Atropine does not only block nicotinic receptors but also acetylcholine at muscarinic receptors
Acetylcholine.
Curare is a competitive inhibitor of acetylcholine. It fights with acetycholine for postsynaptic receptors.
There are several compounds and drugs that may block acetylcholine receptors. They are collectively known as cholinergic antagonists.
Sarcolema receptors
nicotinic and muscarinic
It functions as an Acetylcholine antagonists. Acetylcholine was the first neurotransmitter to be discovered. A nicotinic antagonist inhibits Acetylcholine's receptors.
Acetylcholine receptors at neuromuscular junctions are affected in MG. MG is an autoimmune disorder in which the body produces antibodies against its own protein, the acetylcholine receptor. These antibodies block the receptor, preventing the binding of acetylcholine and inhibiting the function of the receptor, which is to initiate a depolarization in muscle cells that will lead to contraction. Fewer available acetylcholine receptors means greater stimuli, i.e. more acetylcholine has to be released to cause a contraction. This manifests physically as serious weakness resulting from inability to move muscles at will. The name of the disease describes the symptoms quite well (my-, muscle; -a-, without; -sthenia, strength; gravis, heavy, serious).
Acetylcholine
Acetylcholine is the neurotransmitter at the neuromuscular junction.