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The actions of estrogen are mediated by the Estrogen receptor (ER), a dimeric nuclear protein that binds to DNA and controls gene expression. Like other steroid hormones, estrogen enters passively into the cell where it binds to and activates the estrogen receptor. The estrogen:ER complex binds to specific DNA sequences called a Hormone response element to activate the transcription of some 137 ER-regulated genes, of which 89 are direct target genes. Since estrogen enters all cells, its action are dependent on the presence of the ER in the cell. The ER is expressed in specific tissues including the ovary, uterus and breast.

While oestrogens are present in both men and women, they are usually present at significantly higher levels in women of reproductive age. They promote the development of female secondary sexual characteristics, such as breasts, and are also involved in the thickening of the endometrium and other aspects of regulating the menstrual cycle. In males, oestrogen regulates certain functions of the reproductive system important to the maturation of sperm and may be necessary for a healthy libido. Furthermore, there are several other structural changes induced by oestrogen in addition to other functions.

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13y ago
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16y ago


Estrogens are a group of steroid compounds, named for their importance in the estrous cycle, and functioning as the primary female sex hormone.

While estrogens are present in both men and women, they are usually present at significantly higher levels in women of reproductive age. They promote the development of female secondary sex characteristics, such as breasts, and are also involved in the thickening of the endometrium and other aspects of regulating the menstrual cycle. In males estrogen regulates certain functions of the reproductive system important to the maturation of sperm and may be necessary for a healthy libido. Estradiol levels vary through the menstrual cycle, with levels highest just before ovulation.

  • Structural
    • promote formation of female secondary sex characteristics
    • stimulate endometrial growth
    • increase uterine growth
    • maintenance of vessel and skin
    • reduce bone resorption, increase bone formation
  • protein synthesis
    • increase hepatic production of binding proteins
  • coagulation
    • increase circulating level of factors 2,7,9,10, antithrombin III, plasminogen
    • increase platelet adhesiveness
  • Lipid
    • increase HDL, triglyceride, fat depositition
    • decrease LDL
  • Fluid balance
    • salt and water retention
  • gastrointestinal tract
    • reduce bowel motility
    • increase cholesterol in bile
  • Cancer
    • About 80% of breast cancers, once established, rely on supplies of the hormone estrogen to grow: they are known as hormone-sensitive or hormone-receptor-positive cancers. Suppression of production in the body of estrogen is a treatment for these cancers1.

1.http://en.wikipedia.org/wiki/Estrogen

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9y ago

Estrogen, which is found most abundant in women, preforms a wide variety of functions, including: the development of a woman's sexual characteristics during puberty, regulation of the menstrual cycle, and it also is responsible for many of the physical and emotional tumult that a girl goes through during her period. Just before ovulation (a period) a woman's amounts of estrogen and progesterone (another major female hormone) severely drop, triggering the many side affects of a period.

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11y ago

Estrogen a hormone that primarily regulate the growth, development, and function of the female reproductive system which are the ovaries and placenta. It works in accordance to with your body's health to make sure that your periods are normal and do take place when expected and the same applies to pregnancy.

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13y ago

what happens if i do not take estrogen pills after taking out my uterus and cervic

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13y ago

Estrogen is necessary in the female body for the monthly period and is produced in the ovaries. It also helps with the skin and hair.

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12y ago

Crazy Or Astigin

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Q: What does estrogen do?
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