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Law of Independent Assortment (The "Second Law")

The Law of Independent Assortment, also known as "Inheritance Law", states that alleles of different genes assort independently of one another during gamete formation. While Mendel's experiments with mixing one trait always resulted in a 3:1 ratio (Fig. 1) between dominant and recessive phenotypes, his experiments with mixing two traits (dihybrid cross) showed 9:3:3:1 ratios (Fig. 2). But the 9:3:3:1 table shows that each of the two genes are independently inherited with a 3:1 ratio. Mendel concluded that different traits are inherited independently of each other, so that there is no relation, for example, between a cat's color and tail length. This is actually only true for genes that are not linked to each other.

Independent assortment occurs during meiosis I in eukaryotic organisms, specifically metaphase I of meiosis, to produce a gamete with a mixture of the organism's maternal and paternal chromosomes. Along with chromosomal crossover, this process aids in increasing genetic diversity by producing novel genetic combinations.

Of the 46 chromosomes in a normal diploid human cell, half are maternally-derived (from the mother's egg) and half are paternally-derived (from the father's sperm). This occurs as sexual reproduction involves the fusion of two haploid gametes (the egg and sperm) to produce a new organism having the full complement of chromosomes. During gametogenesis - the production of new gametes by an adult - the normal complement of 46 chromosomes needs to be halved to 23 to ensure that the resulting haploid gamete can join with another gamete to produce a diploid organism. An error in the number of chromosomes, such as those caused by a diploid gamete joining with a haploid gamete, is termed aneuploidy.

In independent assortment the chromosomes that end up in a newly-formed gamete are randomly sorted from all possible combinations of maternal and paternal chromosomes. Because gametes end up with a random mix instead of a pre-defined "set" from either parent, gametes are therefore considered assorted independently. As such, the gamete can end up with any combination of paternal or maternal chromosomes. Any of the possible combinations of gametes formed from maternal and paternal chromosomes will occur with equal frequency. For human gametes, with 23 pairs of chromosomes, the number of possibilities is 223 or 8,388,608 possible combinations.[3] The gametes will normally end up with 23 chromosomes, but the origin of any particular one will be randomly selected from paternal or maternal chromosomes. This contributes to the genetic variability of progeny.
His experiments with the breeding of plants such as peas

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8y ago
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10y ago

Mendel crossed pea plants having round green seeds (RRyy) with pea plants having wrinkled yellow seeds (rrYY).

An example of dihybrid crosses

Since the F1 plants are formed after crossing pea plants having green round seeds and pea plants having yellow wrinkled seeds, F1 generation will have both these characters in them. However, as we know that yellow seed colour and round seeds are dominant characters, therefore, the F1 plants will have yellow round seeds.

Then this F1 progeny was self-pollinated and the F2 progeny was found to have yellow round seeds, green round seeds, yellow wrinkled seeds, and green wrinkled seeds in the ratio of 9:3:3:1.

Independent inheritance of two different traits

In the above cross, more than two factors are involved, and these are independently inherited.

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7y ago

One trait does not affect whether another trait will be passed on

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Q: How do Mendel's experiment shows that traits are independently assorted?
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