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Yes. Most of the drugs are metabolized by the liver, as the liver is the organ for metabolism.
Most drugs are excreted in the kidneys or filtered through the liver. You can find drugs in your bloodstream and your urine. Sometimes it is excreted through the sweat.
metabolized in the liver
Most are, the vast majority of drugs being broken down by the liver. Some (e.g. lithium carbonate) however are simply excreted without modification though the kidneys.
Studies show that it is metabolized in the liver and kidneys.
The Liver.
oxycodone is metabolized by the cytochrome isoenzyme CYP2D6 of the liver
yes it is metabolised in liver by oxidation reaction....:)
Kidney
located in the cytoplasm
Ibuprofen is metabolized by the Kidneys and is thus excreted in the Urine. Actually, "...NSAIDs are metabolized by the liver via oxidative and conjugative pathways and have the potential to cause liver injury, with some agents being more hepatotoxic than others" Source: http://www.uic.edu/pharmacy/services/di/liver.htm
Yes. Most of the drugs are metabolized by Liver. Drugs given by mouth are are absorbed in gastrointestinal system. They all pass through portal venous system to Liver. Nature has made this arrangement for 'digested food' so it can be processed at Liver. So many drugs are destroyed here only to more or less degree and rest pass in circulation. This is called as first pass metabolism. You do not have to worry about that and by just increasing the dose you can tackle this problem. After this 'First pass metabolism' drug is distributed in body for it's pharmacological action. It continue to recirculate in body as almost 30 % of body supply goes to Liver and drug gets metabolized in Liver. Liver either oxidize or reduce or hydrolyze it in attempt to 'deactivate' the drug and kidney may excrete it. But sometimes these products of metabolism are as more or less Pharmacologically active and then Liver will make it inactive by adding glucuronic acid or acetyl-ate it or adding glutathione to it, methylate it or sulfate is added. Then drug becomes invariably inactive and excreted by kidney.