What genes are mutated in sickle cell disease?
Mutations in the HBB gene cause sickle cell disease.
A person can only inherit sickle-cell genes if some of their ancestors came from certain regions in Africa where the inhabitants carry sickle-cell genes. A person with one sickle-cell gene has sickle-cell trait, a milder problem. If both father and mother pass on sickle-cell genes, the child, with two genes, will have sickle-cell disease.
Sickle Cell Anemia is Autosomal Recessive. It arises from a mutation on the beta-globin gene of chromosome 11. Because Sickle Cell Anemia is an example of incomplete dominance, a person has the disease if they have two mutated beta-globin genes but only has the trait (is a carrier) if they have only one mutated beta-globin gene.
People can only get sickle-cell disease if their ancestors came from regions in Africa where the inhabitants carry sickle-cell genes. Sickle-cell disease is an inherited condition that originally occurred in African regions where malaria is present. A person who inherits a single sickle-cell gene has a tolerance for malaria and will have fewer symptoms if they become infected with malaria. Therefore, in those regions, sickle-cell genes were beneficial and became widespread. Unfortunately, anyone who inherits…
How many mutated genes are needed to have the diseases cystic fibrosis and sickle cell anemia to be present in a person?
Both cystic fibrosis and sickle cell anemia are single mutation diseases - one mutation in a single gene is enough to cause the disease. However, for cystic fibrosis both alleles of the gene must be mutated for the disease to develop. For sickle cell anemia, only one allele can carry the mutation and some signs of the disorder will be present. Having two alleles with the mutation causes much more significant disease.
Sickle cell disease is inherited, which means it is passed from parent to child. To get sickle cell disease, a child has to inherit two sickle cell genes-one from each parent. When a child inherits the gene from just one parent, that child has sickle cell trait. Having this trait means that you do not have the disease but you are a carrier and could pass the gene on to your children.
Every person, assuming no inheritance abnormalities, receives two copies of a gene, one from their mother and one from their father. Sickle cell is a mutation in the hemoglobin of red blood cells. A sickle-cell carrier is when you inherit one normal gene and one mutated or sickle cell gene, and sickle-cell anemia is when you inherit two mutated genes. The carriers are selected for in populations where malaria has a high frequency. It seems…
SICKLE CELL is an inherited genetic blood disorder. Sickle Cell was the 1st genetic disorder that was ever discovered. In order for a person to have "sickle cell disease" they have to inherit the sickle cell gene from each parent. Sickle cell happened because of a gene mutation that started because of Malaria. Everyone who had the "sickle cell trait" (One sickle cell gene) had a better chance of fighting off Malaria.
What would happen to a baby in the womb if the mother has sickle cell disease and the father has the sickle cell trait?
This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition. This is the genetic make up of the father. The mother has both mutated genes. The baby has a 50:50 chance to have sickle…