What happens when you stop taking mirtazapine mirtazapine?

Although I'm unsure of exactly what happens in the brain when stopping mirtazapine, I do know it must be discontinued very gradually and under close doctor supervision, as physical dependence will develop over time; this is especially important for patients who have used the drug at high doses and/or for long periods of time. Suddenly stopping mirtazapine may cause severe depression, insomnia, anxiety, panic attacks, (all dysphoric states) loss of appetite, worsening of allergies and rarely, manic episodes.