Porphyria cutanea tarda (PCT) presents usually in the third/fourth decades of life. The condition is due to decreased activity of uro-porphyrinogen decarboxylase (UROD).
Skin lesions are vesicles (blisters).
This aliment may be precipitated by ingesting too much iron. In 25% of patient, diabetes may be present. Diagnosis is confirmed by high levels of uroporphyrins in the urine and stool.
Treatment is dependent on the elimination of the triggering factor (remove the iron ). Spontaneous remission may occur with advancing age in some patients.