Conditions and Diseases

What is cirrhosis?

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Wiki User
2016-08-25 07:25:39


Cirrhosis of the liver is a consequence of chronic liver

disease characterized by replacement of liver tissue by fibrotic

scar tissue as well as regenerative nodules, leading to progressive

loss of liver function. Cirrhosis is most commonly caused by

alcoholism and hepatitis C, but has many other possible causes.

Cirrhosis is generally irreversible once it occurs, and treatment

generally focuses on preventing progression and complications. In

advanced stages of cirrhosis the only option is a liver


Sulphasalazine, an inexpensive drug used for arthritis and

inflammatory bowel disease, can reverse the scarring associated

with cirrhosis of the liver, according to scientists at the

University of Newcastle in the UK.

Previously thought to be irreversible, new research on animals

has found that the scarring damage can be reversed with the drug.

If research with humans conforms these findings, it may mean that

use of the drug could eliminate the need for liver transplants.

The scientists will start clinical trials with previously heavy

drinkers who no longer drink and whose livers are heavily


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